- Slight spinal curvature
- blue sclera
- Poor muscle tone
- loose joints
- dentinogenesis imperfecta
- Most cases die within the first year of life due to respiratory failure or intracerebral hemorrhage
- Severe respiratory problems due to underdeveloped lungs
- Severe bone deformity and small stature
- Short stature, spinal curvature and sometimes barrel-shaped rib cage
- Triangular face
- Loose joints (double jointed)
- Discolouration of the sclera (the 'whites' of the eyes are blue)
- Bones fracture easily, especially before puberty
- Short stature, spinal curvature, and barrel-shaped rib cage
- Bone deformity is mild to moderate
- Early loss of hearing
Type V:It is distinguished by "mesh-like" bone appearance.
Type VI:With the same clinical features as Type IV, it is distinguished histologically by "fish-scale" bone appearance.
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